Complement: Increased Efficiency of the Second Component after Treatment with Iodoacetamide
- 25 June 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 148 (3678), 1728-1729
- https://doi.org/10.1126/science.148.3678.1728
Abstract
The apparent activity of the second component of human complement was enhanced by treatment of the purified protein with iodoacetamide. By contrast, treatment with iodoacetic acid or p-chloromercuribenzoate led to inactivation. Treatment with iodoacetamide prevented the effect of p-chloromercuribenzoate and vice versa. Enhanced activity was partly due to increased stability of the otherwise labile intermediate complex consisting of erythrocytes, antibody, and the first, second, and fourth components of complement.This publication has 6 references indexed in Scilit:
- Complement: Inactivation of Second Component by p -HydroxymercuribenzoateScience, 1965
- ISOLATION AND DESCRIPTION OF THE FOURTH COMPONENT OF HUMAN COMPLEMENTThe Journal of Experimental Medicine, 1963
- Complement and HemolysisScience, 1963
- CHROMATOGRAPHIC RESOLUTION OF THE FIRST COMPONENT OF HUMAN COMPLEMENT INTO THREE ACTIVITIESThe Journal of Experimental Medicine, 1963
- Studies on the Second Component of ComplementThe Journal of Immunology, 1961
- Kinetic Studies on Immune HemolysisThe Journal of Immunology, 1954