Planar polarity from flies to vertebrates
Open Access
- 1 February 2004
- journal article
- review article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 117 (4), 527-533
- https://doi.org/10.1242/jcs.00973
Abstract
Planar cell polarity (PCP) has been demonstrated in the epithelium of organisms from flies to humans. Recent research has revealed that the planar organization of cells requires a conserved set of genes, known as the PCP genes. Tbe PCP proteins Frizzled (Fz) and Dishevelled (Dsh) function as key players in PCP signalling. Although Fz and Dsh are also involved in Wingless (Wg)/Wnt signalling, these proteins have independent functions in a non-canonical pathway dedicated to PCP. Reorganization of the cell surface and cytoskeleton is required, and recent work has focused on how cell adhesion molecules (such as Fat, Dachsous and Flamingo) function in this process.Keywords
This publication has 57 references indexed in Scilit:
- Egfr signaling regulates ommatidial rotation and cell motility in theDrosophilaeye via MAPK/Pnt signaling and the Ras effector Canoe/AF6Development, 2003
- Identification of Vangl2 and Scrb1 as planar polarity genes in mammalsNature, 2003
- Fidelity in planar cell polarity signallingNature, 2003
- The Wnt signalling pathwayJournal of Cell Science, 2002
- Developmental Compartments and Planar Polarity in DrosophilaCurrent Biology, 2002
- Regulation of Frizzled by Fat-like Cadherins during Planar Polarity Signaling in the Drosophila Compound EyeCell, 2002
- Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulationNature, 2000
- The frizzled gene of Drosophila encodes a membrane protein with an odd number of transmembrane domainsMechanisms of Development, 1994
- frizzled Gene expression and development of tissue polarity in the Drosophila wingDevelopmental Genetics, 1994
- Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of DrosophilaNature, 1987