Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses
Open Access
- 25 April 2008
- journal article
- Published by Springer Nature in Respiratory Research
- Vol. 9 (1), 36
- https://doi.org/10.1186/1465-9921-9-36
Abstract
Sarcoidosis is an idiopathic granulomatous disease with pathologic and immunologic features similar to tuberculosis. Routine histologic staining and culture fail to identify infectious agents. An alternative means for investigating a role of infectious agents in human pathogenesis involves molecular analysis of pathologic tissues for microbial nucleic acids, as well as recognition of microbial antigens by the host immune system. Molecular analysis for superoxide dismutase A (sodA) allows speciation of mycobacteria. SodA is an abundantly secreted virulence factor that generates cellular immune responses in infected hosts. The purpose of this study is to investigate if target antigens of the sarcoidosis immune response can be identified by molecular analysis of sarcoidosis granulomas.Keywords
This publication has 29 references indexed in Scilit:
- MultipleMycobacteriumantigens induce interferon-γ production from sarcoidosis peripheral blood mononuclear cellsClinical and Experimental Immunology, 2007
- Cellular Recognition of Mycobacterium tuberculosis ESAT-6 and KatG Peptides in Systemic SarcoidosisInfection and Immunity, 2007
- Mycobacterium tuberculosis Complex and Mycobacterial Heat Shock Proteins in Lymph Node Tissue from Patients with Pulmonary SarcoidosisJournal of Clinical Microbiology, 2006
- Diagnoses of chronic beryllium disease within cohorts of sarcoidosis patientsEuropean Respiratory Journal, 2006
- Prospective Evaluation of a Whole-Blood Test Using Mycobacterium tuberculosis -Specific Antigens ESAT-6 and CFP-10 for Diagnosis of Active TuberculosisClinical and Vaccine Immunology, 2005
- Superinfecting mycobacteria home to established tuberculous granulomasNature Immunology, 2004
- Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing AgentNew England Journal of Medicine, 2001
- Identification of Novel HLA-A2-Restricted Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Epitopes Predicted by the HLA-A2 Supertype Peptide-Binding MotifJournal of Virology, 2001
- Endemic Contamination of Clinical Specimens by Mycobacterium gordonaeClinical Infectious Diseases, 2000
- Genetic analysis of superoxide dismutase, the 23 kilodalton antigen of Mycobacterium tuberculosisMolecular Microbiology, 1991