Aggregation of Platelets of Normal and Bordetella pertussis Vaccinated Mice by ATP, ADP, and Sodium Fluoride

Abstract

The results of the present studies have shown that platelets obtained from B. pertussis vaccinated mice were more sensitive to the aggregative action of ATP, ADP, and sodium fluoride than were their normal counterparts. Aggregation initiated by any of these substances was suppressed by exogenous cAMP but was enhanced in the presence of NE. These data suggested a role of adenyl cyclase and adrenergic receptors in the mouse platelet aggregation with the exaggerated responsiveness of ‘pertussis’ components due to either hyperreactive α-type or blockade of the β-type receptors.