Vertical-scanning Mutagenesis of a Critical Tryptophan in the Minor Groove Binding Track of HIV-1 Reverse Transcriptase
Open Access
- 1 November 1998
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 273 (46), 30435-30442
- https://doi.org/10.1074/jbc.273.46.30435
Abstract
No abstract availableKeywords
This publication has 45 references indexed in Scilit:
- A minor groove binding track in reverse transcriptaseNature Structural & Molecular Biology, 1997
- Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant MutantJournal of Molecular Biology, 1996
- Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanismsStructure, 1996
- Role of the "Helix Clamp" in HIV-1 Reverse Transcriptase Catalytic Cycling as Revealed by Alanine-scanning MutagenesisJournal of Biological Chemistry, 1996
- Reduced Frameshift Fidelity and Processivity of HIV-1 Reverse Transcriptase Mutants Containing Alanine Substitutions in Helix H of the Thumb SubdomainPublished by Elsevier ,1995
- Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitorsNature Structural & Molecular Biology, 1995
- Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.Proceedings of the National Academy of Sciences, 1993
- Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an InhibitorScience, 1992
- The Accuracy of Reverse Transcriptase from HIV-1Science, 1988
- Fidelity of HIV-1 Reverse TranscriptaseScience, 1988