Potential Uses of Prostaglandins in Control of Reproductive Cycles of Domestic Animals

Abstract

Prostaglandins, specifically prostaglandin F_2α (PGF_2α) have been shown to be present in high concentrations in the uterine endometrium and maternal cotyledons of sheep. Levels of PGF_2α in ovine endometrium increased during the last few days of the estrous cycle or after insertion of intrauterine devices early in the cycle. Peripheral plasma PGF_2α was increased by estrogen treatment in progesterone-primed, ovariectomized ewes, but endometrial PGF_2α was decreased by progesterone alone in ovariectomized ewes. Exogenous PGF_2α induced luteal regression in sheep with functional corpora lutea in ovaries transplanted to the neck and in cattle during days 5 through 18 of the estrous cycle or during pregnancy. Preliminary reports from several laboratories during 1972 suggest that PGF_2α is worthy of further study as an agent for control of ovulation. Data on conception rates, dose and route of administration, timing of insemination following treatment, side effects, other prostaglandins and analogues are needed in order to assess the value of prostaglandins for control of ovulation. Copyright © 1973. American Society of Animal Science . Copyright 1973 by American Society of Animal Science.