Cyclic AMP-Dependent Protein Kinase: Pivotal Role in Regulation of Enzyme Induction and Growth
- 28 November 1975
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 190 (4217), 896-898
- https://doi.org/10.1126/science.171770
Abstract
Dibutyryl cyclic adenosine 3',5'-monophosphate (cyclic AMP) produces phosphodiesterase induction, growth arrest, and cytolysis in S49 lymphoma cells. The striking parallelism between protein kinase activity that is dependent on cytosol cyclic AMP and cellular responses to dibutyryl cyclic AMP in wild-type cells and three classes of clones resistant to cyclic AMP indicates that protein kinase mediates cyclic AMP regulation of growth and enzyme induction in S49 cells.Keywords
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