Hyperactivity and Brain Catecholamines in Lead-Exposed Developing Rats
- 7 December 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 182 (4116), 1022-1024
- https://doi.org/10.1126/science.182.4116.1022
Abstract
Newborn rats that suckled mothers eating a diet containing 4 percent lead carbonate display hyperactivity, aggressiveness, and excessive stereotyped behavior starting at 4 weeks of age. There is an eightfold increase in the concentration of lead in brain, no change in norepinephrine, but a 20 percent decrease in dopamine relative to coetaneous controls. This suggests a relationship between central nervous system dysfunction due to lead and dopamine metabolism in brain.Keywords
This publication has 9 references indexed in Scilit:
- Atomic absorption determination of zinc, copper, cadmium, and lead in tissues solubilized by aqueous tetramethylammonium hydroxideAnalytical Biochemistry, 1973
- Dopamine, noradrenaline and 5-hydroxy-tryptamine in relation to motor activity, fighting and mounting behaviour: I. l-DOPA and dl-threo-dihydroxyphenylserine in combination with Ro 4-4602, pargyline and reserpineNeuropharmacology, 1973
- Tremor and Involuntary Movements in Monkeys: Effect of L-Dopa and of a Dopamine Receptor Stimulating AgentScience, 1973
- LEAD AND HYPERACTIVITYThe Lancet, 1972
- Considerations on the development of experimental lead encephalopathyVirchows Archiv, 1971
- Syndromes of "Minimal Cerebral Damage"Pediatric Clinics of North America, 1968
- Lead encephalo-myelopathy of the suckling rat and its implications on the porphyrinopathic nervous diseasesActa Neuropathologica, 1966
- THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCEAmerican Journal of Psychiatry, 1965
- Morphology and morphogenesis of lead encephalopathyActa Neuropathologica, 1965