A COENZYME CONTAINING PSEUDOVITAMIN B 12
- 15 November 1958
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 44 (11), 1093-1097
- https://doi.org/10.1073/pnas.44.11.1093
Abstract
The isolation of a coenzyme form of pseudovitamin B12 is reported which is required for the decomposition of glutamate by particle-free extracts of Clostridium tetanomorphum. The coenzyme is involved in the rearrangement of the C skeleton of glutamate to form a branched-chain amino acid, [beta]-methylaspartate. Chemical analysis indicates the coenzyme contains one or more purine moieties. The light-sensitivity of the coenzyme and the large shift of the peak in the visible region to longer wave lengths on exposure to light suggest that a functionally important substituent group is attached both to C and to some part of the conjugated double-bond system of the prophyrin-like structure.This publication has 6 references indexed in Scilit:
- Biochemical Functioning of Vitamin B12Nature, 1958
- Role of Vitamin B12 in Nucleic Acid Metabolism. V. Liver Deoxyriboaldolase Activity.Experimental Biology and Medicine, 1957
- THE RÔLE OF α-KETOGLUTARATE AND MESACONATE IN GLUTAMATE FERMENTATION BY CLOSTRIDIUM TETANOMORPHUMJournal of Biological Chemistry, 1956
- The activation of protein sulfhydryl groups by vitamin B12Archives of Biochemistry and Biophysics, 1956
- ROLE OF VITAMIN-B-12 IN NUCLEIC ACID METABOLISM .4. METABOLISM OF C-14-LABELED THYMIDINE BY LACTOBACILLUS LEICHMANNII1956
- THE INFLUENCE OF VITAMIN B12 ON CARBOHYDRATE AND LIPIDE METABOLISMJournal of Biological Chemistry, 1954