Chemotherapy with cyclophosphamide, vincristine, cytosine arabinoside, and prednisone (COAP) in childhood acute lymphoblastic leukemia (ALL)
- 1 January 1977
- journal article
- research article
- Published by Wiley in Medical and Pediatric Oncology
- Vol. 3 (4), 359-364
- https://doi.org/10.1002/mpo.2950030406
Abstract
Three groups of children with acute lymphoblastic leukemia (ALL) were treated with intermittent cyclophosphamide, vincristine, cytosine arabinoside, and prednisone (COAP). Group A (no prior relapse) and Group B (prior single‐agent relapse) received COAP after 12 months on another chemotherapy regimen. Children in Group C (prior relapse on multiagent regimens) received COAP following A‐COAP (asparaginase plus COAP) reinduction. Median disease‐free survival after beginning COAP was not reached for Group A, but was only 7 months for Groups B and C. As of November 1976, there were 8 of 15 Group A patients, 1 of 12 Group B patients, and 1 of 28 Group C patients who had remained disease‐free from 38 to 60 (median 54.5) months and were off chemotherapy. COAP has activity in childhood ALL. However, effectiveness in markedly diminished in patients with prior bone marrow relapse.Keywords
This publication has 4 references indexed in Scilit:
- Development of an effective treatment program for childhood acute lymphocytic leukemia: A preliminary reportMedical and Pediatric Oncology, 1976
- Interrupted vs. continued maintenance therapy in childhood acute leukemiaCancer, 1975
- Combined modality therapy of acute lymphocytic leukemiaCancer, 1975
- Cessation of Therapy during Complete Remission of Childhood Acute Lymphocytic LeukemiaNew England Journal of Medicine, 1974