Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.
Open Access
- 1 February 1987
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 262 (4), 1842-1847
- https://doi.org/10.1016/s0021-9258(19)75716-0
Abstract
No abstract availableThis publication has 35 references indexed in Scilit:
- Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucoseCell, 1986
- HORMONAL REGULATION OF MAMMALIAN GLUCOSE TRANSPORTAnnual Review of Biochemistry, 1986
- Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cellsNature, 1985
- Human insulin receptor and its relationship to the tyrosine kinase family of oncogenesNature, 1985
- In VitroDeletional Mutagenesis for Bacterial Production of the 20,000-Dalton Form of Human Pituitary Growth Hormone.DNA, 1983
- Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequencesNature, 1981
- “Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein AAnalytical Biochemistry, 1981
- Insulin‐like growth factor: insulin or serum increase phosphorylation of ribosomal protein S6 during transition of stationary chick embryo fibroblasts into early G1 phase of the cell cycleFEBS Letters, 1979
- Insulin‐Like Growth Factors I and II: Some Biological Actions and Receptor Binding Characteristics of Two Purified Constituents of Nonsuppressible Insulin‐Like Activity of Human SerumEuropean Journal of Biochemistry, 1978
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970