Effects of 3‐OM‐dopa on monoarnine metabolism in rat brain
- 1 March 1983
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 33 (3), 278
- https://doi.org/10.1212/wnl.33.3.278
Abstract
We studied the effects of 3-methoxy, 4-hydroxy-phenylalanine (3-OM-dopa) on monoamine turnover, L-3-4-dihydroxy-phenylalanine (L-dopa) reversal of catecholamine depletion induced by a-methyl-paratyrosine (α-MT), and the passage of L-dopa across the blood-brain barrier of the rat brain. 3-OM-dopa did not affect monoamine turnover but interfered with restoration of dopamine levels by L-dopa. In addition, systemic 3-OM-dopa decreased brain uptake of 14C-∼-dopa. High 3-OM-dopa blood levels may interfere with the therapeutic response to L-dopa in parkinsonism.This publication has 3 references indexed in Scilit:
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