The I-J subregion codes for determinants on suppressor factor(s) which limit the contact sensitivity response to picryl chloride
Open Access
- 1 July 1977
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 146 (1), 293-296
- https://doi.org/10.1084/jem.146.1.293
Abstract
The cell-mediated immune reactivity (CMI) of mice to contact chemicals such as picryl chloride (PCl) is influenced by thymus-derived suppressor T lymphocytes. The development of these suppressor T lymphocytes is stimulated by the i.v. administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS). The antigen-specific SF [suppressor factor] which limits the CS [contact sensitivity] response to PCl apparently bears I-J determinants, implying that analogous suppressive regulatory mechanisms in CMI as well as antibody responses may be determined by genes of 1 subregion of the H-2 complex.This publication has 7 references indexed in Scilit:
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