Effect of histamine on the hippocampal neurons in guinea-pigs
- 1 May 1984
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 14 (3-4), 538-542
- https://doi.org/10.1007/bf01973866
Abstract
Histamine produced an excitatory effect on CA3 pyramidal cells in hippocampal slices of guinea-pigs. The amplitude of population spikes and EPSPs was augmented by histamine at concentrations of 10−7 to 10−6 M. Cimetidine but not pyrilamine prevented the stimulatory effect. The histamine effect was mimicked by dimaprit but not by 2-pyridylethylamine. It is concluded that histamine has a facilitatory influence on the hippocampal excitatory system via H2 receptor.This publication has 25 references indexed in Scilit:
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