Lack of effect of ranitidine on the disposition of lignocaine.

Abstract

Cimetidine has been shown to alter the disposition of lignocaine and other drugs that are highly extracted by the liver. In a placebo controlled study ranitidine (150 mg twice daily) did not alter the elimination half‐life, systemic clearance or distribution of lignocaine (mg/kg) in six healthy subjects. The interaction with cimetidine appears to be unrelated to histamine H2‐receptor antagonism.