The synthesis of lipids in the livers of rats treated with pituitary growth hormone

Abstract

The effect of administration of pituitary growth hormone on the rats of incorporation of C14 from pyruvate and acetate into CO2, fatty acids, phospholipids and cholesterol by rat-liver slices was investigated. There was no difference in the rate of production of CO2 from any of these substrates in normal or treated rats. The C14 of (carboxy-C14) pyruvate was only found in the CO2. Growth hormones reduced the rate of incorporation of C14 from ([alpha]-C14) pyruvate and (carboxy-C14) acetate into both fatty acids and phospholipids. The rate of incorporation of C14 into cholesterol appeared to be stimulated by growth hormone.