The nature of the collagen cross-links in bone in the chronic uraemic state
- 1 January 1975
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 145 (1), 119-120
- https://doi.org/10.1042/bj1450119
Abstract
The cross-links from NaB3H4-reduced bone collagen of chronically uraemic rats and pairfed controls were compared. The ratio of the reduced cross-links deltadelta'-dihydroxylysinonorleucine to delta-hydroxylysinonorleucine was significantly increased in the uraemic animals. The observed increment in the dihydroxylysinonorleucine:hydroxylysinonorleucine ratio was accentuated as the uraemic state advanced. The data indicate that osteodystrophy of chronic renal insufficiency is characterized by an alteration of the quantitative relations between cross-links and aldehydic precursors of bone collagen.Keywords
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