Six hundred and twelve patients with cancer of the larynx were treated at the Temple University Hospital from 1930 to 1947 inclusive (table 1). Surgical treatment was used in 453 cases (laryngofissure or thyrotomy, a form of partial laryngectomy, in 209 and total laryngectomy in 244), and irradiation was used in 159 cases. Five year end results can now be computed only on three hundred and seventy-one treatments given through December 1942. Of the 118 patients treated by laryngofissure, 102 were determinate. By determinate we mean that they did not die of other cause withinfive years of treatment and were traced. Prior to 1940 the laryngectomies done at the Temple University Hospital were done by others, and we include in the five year analysis only the 39 cases in which the operation was performed by us in the years 1940 to 1942 inclusive; of these, 35 were determinate. There