URINARY VOLUME AND EXCRETION OF OESTROGENS IN LATE PREGNANCY

Abstract

The relationship between urinary volume and estrone, 17[beta]-estradiol and estriol was studied initially within the range of spontaneous variation and subsequently with the aid of water loads and diuretics. The spontaneous variations in urinary output showed no definite correlation with the excretion of estrogens, while massive hydration led to increased excretion. With hydrochlorothiazide a clear positive correlation was obtained. These results support the view that reabsorption of the above-mentioned estrogens occurs in the region of the proximal tubules.