Staging Laparotomy in Hodgkinʼs Disease

Abstract

Staging laparotomy was performed in 111 patients with Hodgkin''s disease. The operation included multiple liver and lymph node biopsies and, excepting 3 patients, splenectomy. The histopathology was reviewed and the 111 patients were classified as follows: nodular sclerosis, 74; mixed cellularity, 28; lymphocyte predominance, 7 and undetermined, 2. There were no deaths. Wound, pulmonary or urinary tract complications occurred in 11 patients. One case of postoperative thrombophlebitis occurred and in another case small bowel obstruction developed, and resolved without reoperation. The pathologic stage (PS) following laparotomy was unchanged from the clinical stage (CS) in 64%, reduced in 20% and advanced in 16%. Therapy was altered in 38% of the patients. Lymphangiography in 103 patients was interpreted as showing lymph node involvement in 38, equivocal involvement in 11, and non involvement in 54. Among the 92 examinations reported as positive or negative, 77% were confirmed histopathologically, 21% were falsely positive and 2% were falsely negative. The spleen was positive for Hodgkin''s disease in 39% of cases, and in these patients with positive spleens there was no reason to suspect intraabdominal involvement preoperatively in 2.