Antigrowth Effect of Some Inhibitors of Polyamine Synthesis on Transplantable Prostate Cancer
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 40 (1), 57-62
- https://doi.org/10.1159/000225692
Abstract
Inhibitors of polyamine synthesis were tested for therapeutic effectiveness on transplantable prostate cancer [in rats]. Inhibition of ornithine decarboxylase or S-adenosyl-L-methionine decarboxylase (AMDC) or .alpha.-difluoromethylornithine (DFMO) or methylglyoxal-bis[guanylhydrazone] (MGBG), respectively, was associated with significant antitumor effect. The combination of DFMO with MGBG was not only more effective but no more toxic than MGBG alone. Combination of MGBG with 9-B-D-arabinofuranosyladenine, an indirect effector of SAMDC, failed to increase therapeutic effectiveness of MGBG.Keywords
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