Zwitterionic Chitosan Derivatives for pH-Sensitive Stealth Coating
- 10 August 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 11 (9), 2352-2358
- https://doi.org/10.1021/bm100481r
Abstract
Zwitterionic chitosan, a chitosan derivative with a unique pH-dependent charge profile, was employed to create a stealth coating on the cationic surface of drug carriers. Zwitterionic chitosans were synthesized by amidation of chitosan with succinic anhydride. The succinic anhydride-conjugated chitosan had an isoelectric point, which could be easily tuned from pH 4.9 to 7.1 and showed opposite charges below and above the isoelectric point. The succinic anhydride-conjugated chitosan was able to inhibit the protein adsorption to the cationic surface at physiological pH, compatible with blood components and well tolerated upon intraperitoneal injection. The succinic anhydride-conjugated chitosan has the potential to serve as a coating material to prevent protein adsorption to cationic surfaces, which can be removed in a pH-responsive manner.Keywords
This publication has 44 references indexed in Scilit:
- Gene delivery through the use of a hyaluronate-associated intracellularly degradable crosslinked polyethyleneimineBiomaterials, 2009
- In Vivo Evaluation of Doxorubicin-Loaded Polymeric Micelles Targeting Folate Receptors and Early Endosomal pH in Drug-Resistant Ovarian CancerMolecular Pharmaceutics, 2009
- Doxorubicin‐Loaded Polymeric Micelle Overcomes Multidrug Resistance of Cancer by Double‐Targeting Folate Receptor and Early Endosomal pHSmall, 2008
- Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistanceJournal of Controlled Release, 2008
- Chitosan and its derivatives for tissue engineering applicationsBiotechnology Advances, 2007
- Sheddable Coatings for Long-Circulating NanoparticlesPharmaceutical Research, 2007
- Fluorescent resonance energy transfer: A tool for probing molecular cell–biomaterial interactions in three dimensionsBiomaterials, 2007
- TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumorsJournal of Controlled Release, 2006
- “SMART” Drug Delivery Systems: Double-Targeted pH-Responsive Pharmaceutical NanocarriersBioconjugate Chemistry, 2006
- Modified alginate matrices for the immobilization of bioactive agentsBiotechnology and Applied Biochemistry, 2004