Hereditary Diabetes insipidus in Rats
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in Neuroendocrinology
- Vol. 31 (3), 189-193
- https://doi.org/10.1159/000123072
Abstract
Compared to heterozygous Brattleboro animals, homozygous (diabetes insipidus) rats exhibited higher steady-state levels of serotonin in the mesencephalon, septum and striatum. These differences disappeared upon the administration of pargyline, suggesting a decreased accumulation of serotonin. The norepinephrine level was higher in the mesencephalon, while the disappearance rate (.alpha.-methyl-p-tyrosine) was accelerated in the septum and decreased in the hypothalamus. The lower striatal dopamine level was associated with a decreased disappearance rate. The altered monoamine metabolism might be associated with the known endocrine and behavioral disturbances of the homozygous rats.This publication has 3 references indexed in Scilit:
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- Intra- and extrahypothalamic vasopressin and oxytocin pathways in the ratCell and tissue research, 1978
- Morphology of the Neurosecretory System in Rats Homozygous and Heterozygous for Hypothalamic Diabetes Insipidus (Brattleboro Strain)Endocrinology, 1965