Influence of phenobarbitone pretreatment on disposition of amidopyrine and its metabolites in rat
- 1 September 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 32 (1), 619-623
- https://doi.org/10.1111/j.2042-7158.1980.tb13017.x
Abstract
Plasma concentration-time profiles for amidopyrine and its primary desmethyl metabolite have been determined in control rats and in rats pretreated with phenobarbitone. The kinetics of both compounds indicate enhanced clearance following pretreatment. Metabolite excretion in urine, bile and breath support the plasma data. It would appear that phenobarbitone pretreatment results in quantitative but not qualitative changes in the metabolism of amidopyrine in rat.This publication has 13 references indexed in Scilit:
- Amidopyrine disposition in ratJournal of Pharmacy and Pharmacology, 1979
- Heterogeneous response of hepatic mixed function oxidases to chronic phenobarbital administrationBiochemical Pharmacology, 1979
- Theoretical Relationships between Area under the Curve and Route of Administration of Drugs and Their Precursors for Evaluating Sites and Pathways of MetabolismJournal of Pharmaceutical Sciences, 1978
- IN VIVO PARAMETERS OF DRUG METABOLISM—DIFFERENCES IN SPECIFICITY TOWARDS INDUCING AGENTSPublished by Elsevier ,1977
- Metabolism and excretion of aminopyrine in man.CHEMICAL & PHARMACEUTICAL BULLETIN, 1976
- SOME CHARACTERISTICS OF HEPATIC MICROSOMAL SYSTEMS WHICH METABOLIZE AMINOPYRINE IN RAT AND RABBIT1968
- Factors that affect the stimulation of the microsomal drug enzymes induced by foreign compoundsAdvances in Enzyme Regulation, 1963
- Drug TolerancePublished by Wiley ,1962
- A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counterAnalytical Biochemistry, 1960
- THE FATE OF AMINOPYRINE (PYRAMIDON) IN MAN AND METHODS FOR THE ESTIMATION OF AMINOPYRINE AND ITS METABOLITES IN BIOLOGICAL MATERIAL1950