Potentiation of the chemotherapeutic action of 5-fluorouracil by combination with cytidine or guanosine on HRS-Sarcoma
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 93 (3), 241-244
- https://doi.org/10.1007/bf00964579
Abstract
The chemotherapeutic action of 5-fluorouracil monotherapy on HRS-Sarcoma in mice was compared with those of 5-fluorouracil nucleoside combinations (thymidine, cytidine or guanosine). The curative action of 5-fluorouracil was potentiated without increasing its toxicity, when cytidine or guanosine were applied at definite intervals before or after 5-fluorouracil. Die chemotherapeutische Wirkung von 5-Fluorouracil wurde am HRS-Sarkom der Maus mit 5-Fluorouracil-Nucleois-Kombinationen (Thymidin, Cytidin, Guanosin) verglichen. Die curative Wirkung von 5-Fluorouracil wurde ohne Zunahme der Toxizität potenziert, wenn die Nucleoside Cytidin oder Guanosin in bestimmtem Zeitintervall vor oder nach der 5-Fluorouracil-Applikation erfolgte.Keywords
This publication has 11 references indexed in Scilit:
- Potentiation by guanine nucleosides of the growth-inhibitory effects of adenosine analogs on L1210 and sarcoma 180 cells in culture.1976
- Potenzierung der chemotherapeutischen Wirkung von Adriamycin durch bestimmte NukleosidePublished by Springer Nature ,1975
- Potentiation of the chemotherapeutic action of bleomycin by combination with inosine on HRS-sarcomaCancer Letters, 1975
- [Clinical experiences with a combination therapy of metastasising genital and mammary carcinomas (author's transl)].1974
- Metabolic conditioning and metabolic actuation: experimental approaches to cancer chemotherapy involving combinations of metabolites and antimetabolites.1974
- 5-Fluorouracil and Derivatives in Cancer Chemotherapy II: Possible In Vivo Formation and Stabilization of 5-Fluoro-2′-deoxyuridineJournal of Pharmaceutical Sciences, 1972
- [Potentiation of the chemotherapeutic effect of vinblastine by thymidine].1972
- [Synergistic effect of the combination of thymidine and cyclophosphamide on Ehrlich ascites tumor].1970
- Synergismus der chemotherapeutischen Wirkung einer Kombination von Thymidin und Endoxan (Cyclophosphamid) beim Ehrlich-Ascites-TumorZeitschrift für Krebsforschung und Klinische Onkologie, 1970
- STUDIES ON FLUORINATED PYRIMIDINES .15. INHIBITION OF INCORPORATION OF FORMATE-C14 INTO DNA THYMINE OF EHRLICH ASCITES CARCINOMA CELLS BY 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE AND RELATED COMPOUNDS1962