In vitro Activity of Six Quinolone Derivatives against Neisseria gonorrhoeae
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 34 (4), 315-317
- https://doi.org/10.1159/000238585
Abstract
The in vitro activities of six quinolone derivatives, rosoxacin, pefloxacin, ofloxacin, ciprofloxacin, A-56619 and A-56620, were compared with those of penicillin, cefotaxime, spectinomycin, chloramphenicol, tetracycline and erythromycin against 50 nonpenicillinase-producing and 15 penicillinase-producing Neisseria gonorrhoeae strains. Ciprofloxacin was the most active compound in vitro (MIC50, 0.004 mg/l) followed by ofloxacin and A-56620 (MIC50, 0.008 mg/l), A-56619 and cefotaxime (MIC50, 0.016 mg/l). The six quinolones are highly active against all the strains tested but 2, with decreased sensitivity.Keywords
This publication has 1 reference indexed in Scilit:
- In vitro activity of A-56619 (difloxacin), A-56620, and other new quinolone antimicrobial agents against genital pathogensAntimicrobial Agents and Chemotherapy, 1986