Improved Compatibility of ALG Therapy by Application of Aggregate Free Globulin
- 1 January 1976
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 52 (1-4), 227-234
- https://doi.org/10.1159/000231686
Abstract
Horse anti-human lymphocyte globulin (ALG) solutions contain, like human γ-globulin preparations, a varying amount of IgG aggregates, which increase during longer periods of storage. Aggregate formation does not impair the immunosuppressive potency of ALG, as has been shown by prolongation of skin allograft survival time in primates. Deaggregated ALG, which can be obtained by ultracentrifugation at 100,000 g over 2 h, is less immunogenic than aggregate containing ALG. The clinical compatibility of ALG was significantly improved by ultracentrifugal deaggregation.Keywords
This publication has 5 references indexed in Scilit:
- Cumulation and elimination of horse-anti-dog lymphocyte and normal horse gammaglobulin in dogsZeitschrift für Die Gesamte Experimentelle Medizin, 1976
- Clinical Reactions and Serologic Changes After the Administration of Heterologous Antilymphocyte Globulin to Human Recipients of Renal HomograftsAnnals of Internal Medicine, 1968
- Gamma Globulin and Molecular Mechanisms in Hypersensitivity Reactions (Part 1 of 2)Published by S. Karger AG ,1963
- ROLE OF AGGREGATED GAMMA-GLOBULINS IN ANTICOMPLEMENTARY ACTIVITY OF HUMAN AND ANIMAL SERA1962
- THE ADSORPTION OF PROTEINS ON ERYTHROCYTES TREATED WITH TANNIC ACID AND SUBSEQUENT HEMAGGLUTINATION BY ANTIPROTEIN SERAThe Journal of Experimental Medicine, 1951