Temperature and the Bacteriostatic Action of Sulfathiazole and Other Drugs. II. Streptococcus pyogenes.

Abstract

Summary The effect of sulfathiazole, p-aminobenzoic acid and urea, separately and in combinations, on the growth rate of Streptococcus pyogenes has been studied as a function of temperature. The bacteriostatic action of all these substances has been shown to increase with temperature. The sulfonamide-like action of p-aminobenzoic acid at higher temperatures is considered to be of particular significance. With the method used, urea shows no synergistic action with sulfathiazole on this organism. These results with Streptococcus pyogenes have been found to be analogous to those obtained with E. coli.