CYCLIC AMP AND ALLERGIC HISTAMINE RELEASE. INFLUENCE OF METHYLXANTHINES ON RAT MAST CELLS
- 1 June 1977
- Vol. 32 (3), 183-191
- https://doi.org/10.1111/j.1398-9995.1977.tb01348.x
Abstract
Both isobutylmethylxanthine and theophylline increased the level of cyclic[c]AMP in rat mast cells. Theophylline reduced the allergic histamine release, whereas isobutylmethylxanthine caused a pronounced potentiation of the histamine release. The hypothesis of an inverse relationship between the level of cAMP in mast cells and histamine release is inadequate.Keywords
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