Biological Studies with α-Dehydrobiotin
- 1 October 1969
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 100 (1), 42-6
- https://doi.org/10.1128/jb.100.1.42-46.1969
Abstract
A growing culture of Streptomyces lydicus converted biotin-(14)C to alpha-dehydrobiotin-(14)C. The conversion was demonstrated by isolating crystalline alpha-dehydrobiotin-(14)C from fermentation liquors supplemented with biotin-(14)C. The addition of pimelic acid-(14)C to the growing culture did not produce any radioactive alpha-dehydrobiotin. alpha-Dehydrobiotin did not substitute for biotin in Lactobacillus plantarum or in Saccharomyces cerevisiae. Antimicrobial activity of alpha-dehydrobiotin was abolished by avidin. alpha-Dehydrobiotin appears to be different from several biotin vitamers described in the literature. It is concluded that alpha-dehydrobiotin is a product of biotin catabolism in S. lydicus.Keywords
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