Interaction between prostaglandins E and F given intradermally in the rat

Abstract

1 Increases in permeability observed after intradermal injection of prostaglandins PGE₁ or PGE₂ (0.1 μg) into rats were greatly reduced when they were given in admixture with PGF_2α. This effect was not seen with PGF_1α at doses of 0.5–1 μg. 2 Effects of the histamine releasing agent compound 48/80 (25 ng) were inhibited by PGF_2α (0.5 μg) but not by PGF_lα (0.5 μg). 3 Responses to histamine (1 μg), 5-hydroxytryptamine (0.1 μg) and brady-kinin (1 μg), which have a direct action on the microvasculature, were not significantly altered by PGF_2α (0.5 μg). 4 It is concluded that PGF_2α probably acts by interfering with the release of mast cell histamine by PGE_l, PGE₂ and compound 48/80.