Comparative in-vitro activity of CP-99219, a new quinolone, against respiratory pathogens

Abstract

The comparative in-vitro activity of CP-99219, a new quinolone, against Haemophilus influenzae (150 isolates), Moraxella catarrhalis (100), Streptococcus pneumoniae (80) and Group A β-haemolytic streptococci (40) was determined using an agar dilution technique. CP-99219 was the most active compound tested against M. catarrhalis (MIC₅₀=0.015 mg/L, MIC₉₀=0.03 mg/L). Ceftriaxone, CP-99219 and ciprofloxacin were the three most active agents tested against H. influenzae. CP-99219 showed good activity, 16-fold greater than that of ciprofloxacin, against S. pneumoniae (MIC₅₀=0.12 mg/L; MIC₉₀=0.25 mg/L) and was also active against Group A streptococci. Clinical studies regarding the use of CP-99219 in respiratory tract infections seem indicated.