Fertility patterns prior to testicular cancer diagnosis
- 1 April 2005
- journal article
- Published by Springer Nature in Cancer Causes & Control
- Vol. 16 (3), 295-299
- https://doi.org/10.1007/s10552-004-4024-2
Abstract
Although prenatal factors are associated with testicular cancer etiology, few studies have examined the reproductive profiles of men prior to diagnosis. This case–control study investigated fertility patterns prior to testicular cancer diagnosis by comparing pregnancies fathered by 201 men with testicular cancer and those fathered by 204 age- and neighborhood-matched controls. Regardless of histology, men with testicular cancer were less likely to have ever fathered a live-born infant (OR 0.67, 95% CI 0.42–1.06) and had fewer offspring than control men (means 1.8 and 2.1, respectively). Cases were more likely than controls to report having an infertility diagnosis (OR 9.47, 95% CI 1.19–75.2) or a low sperm count (OR 5.85, 95% CI 1.28–26.7) prior to cancer diagnosis. No differences were observed for pregnancy loss. These results indicate that men with testicular cancer may have impaired fecundity and fertility as evidenced by an infertility diagnosis or low sperm count and fewer live births. Further research is needed to determine the extent to which reproductive factors are involved in the etiology of testicular cancer.This publication has 15 references indexed in Scilit:
- Risk of testicular cancer in subfertile men: case-control studyBMJ, 1999
- How Accurate Is Male Recall of Reproductive Information?American Journal of Epidemiology, 1998
- Reduced Ratio of Male to Female Births in Several Industrial CountriesJAMA, 1998
- ARTICLES: Testicular Nonseminoma and Seminoma in Relation to Perinatal CharacteristicsJNCI Journal of the National Cancer Institute, 1996
- Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, AustraliaBritish Journal of Cancer, 1991
- Testis cancer: Post‐natal hormonal factors, sexual behaviour and fertilityInternational Journal of Cancer, 1989
- Testicular cancer in young men: the search for causes of the epidemic increase in the United States.Journal of Epidemiology and Community Health, 1987
- Carcinoma‐in‐situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytomaInternational Journal of Andrology, 1987
- Testicular cancer and antecedent diseasesBritish Journal of Cancer, 1987
- Sports activities and risk of testicular cancerBritish Journal of Cancer, 1982