Regulation of acetylcholinesterase appearance at neuromuscular junctions in vitro
- 1 January 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 283 (5744), 264-267
- https://doi.org/10.1038/283264a0
Abstract
The appearance of acetylcholinesterase (AChE) at newly formed nerve–muscle synapses depends on synaptic transmission. Synapses form when cultures are grown in the presence of acetylcholine receptor antagonists, but AChE does not accumulate at these synapses. The important component of transmission seems to be muscle activity. Treatment with dibutyryl cyclic GMP mimics muscle activity, directly inducing synaptic AChE appearance.Keywords
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