THE LATHYROGENIC EFFECT OF ISONICOTINIC ACID HYDRAZIDE (INAH) ON THE CHICK EMBRYO AND ITS REVERSAL BY PYRIDOXAL

Abstract

When applied to the chorioallantoic membrane of the chick embryo, isoniazid produced an increase in the fragility of the embryo and in the amount of collagen which was extractable from the bones with cold 1 M NaCl. The administration of pyridoxal reversed these phenomena almost completely. The effect of isoniazid differed from that of [beta]-aminopropionitrile in that the latter was of greater magnitude, and was not affected by pyridoxal; whereas 0-aminopropioni-trile caused skeletal deformities, isoniazid even at 12 times the concentration produced no deformities. The aldehyde group of pyridoxal was necessary for its interaction with isoniazid.