Cocaine-induced place conditioning: importance of route of administration and other procedural variables
- 1 January 1988
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 94 (1), 119-125
- https://doi.org/10.1007/bf00735892
Abstract
It has been shown that pretreatment with dopamine (DA) receptor blockers disrupts the effect of intravenously (IV) and intracerebrally (ICV), but not intraperitoneally (IP) administered cocaine on place preference conditioning (PPC). The present study was undertaken to further evaluate possible differences between IV and IP cocaine PPC. To this end, several factors which may differentially influence IV and IP cocaine PPC were examined. Firstly, dose-response effects were studied. Intravenous cocaine produced PPC within a narrow dose range (0.5–2.5 mg/kg). Animals receiving IV injections of 5 and 10 mg/kg cocaine experienced convulsions and did not show PPC. For IP cocaine a 10-fold increase in dose (10 mg/kg) and twice the number of training trials was required in order to obtain PPC equal in magnitude to that with IV cocaine (0.5 mg/kg; two trials). Cocaine PPC was retained at least 1 month. Following IV cocaine preference developed for the side associated with the drug regardless of whether the conditioning was to the least or most preferred side. After IP cocaine, preference developed for the drug side only when the drug was paired with the least preferred side. Rats trained with IV, but not IP, cocaine significantly preferred the drug familiar side to a novel compartment. Preference for the IV or IP cocaine side developed regardless of whether testing was carried out in the drugged or undrugged state, excluding possible state-dependent effects as an explanation of the cocaine PPC. The results show PPC procedure to be a valid test for evaluating rewarding properties of IV cocaine. However, they fail to show rewarding effects of IP cocaine.This publication has 19 references indexed in Scilit:
- Intravenous cocaine-induced place preference: attenuation by haloperidolBehavioural Brain Research, 1987
- The conditioned place preference is affected by two independent reinforcement processesPharmacology Biochemistry and Behavior, 1985
- Place preference conditioning with methylphenidate and nomifensineBrain Research, 1985
- Neuroleptics block the positive reinforcing effects of amphetamine but not of morphine as measured by place conditioningPharmacology Biochemistry and Behavior, 1985
- Conditioned place preference with morphine: The effect of extinction training on the reinforcing CRPharmacology Biochemistry and Behavior, 1984
- Cocaine-induced place preference conditioning: Lack of effects of neuroleptics and 6-hydroxydopamine lesionsBrain Research, 1982
- Dopaminergic substrates of amphetamine-induced place preference conditioningBrain Research, 1982
- Temporal properties of the rewarding and aversive effects of amphetamine in ratsPharmacology Biochemistry and Behavior, 1980
- Rewarding and aversive effects of morphine: Temporal and pharmacological propertiesPharmacology Biochemistry and Behavior, 1980
- Drugs and Reinforcement Mechanisms: A Critical Review of the Catecholamine TheoryAnnual Review of Pharmacology and Toxicology, 1978