Philadelphia Chromosome with T(6;22) (P25;q12)
- 8 April 1976
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 294 (15), 827-828
- https://doi.org/10.1056/nejm197604082941508
Abstract
The introduction of chromosome analysis in various blood disorders has proved the high specificity of the Philadelphia chromosome — a G22 member with deleted long arms — in the diagnosis of chronic myelocytic leukemia.1 , 2 More recently, using Giemsa and fluorescence banding technics, Rowley was able to locate the deleted part of chromosome 22 on the long arms of a No. 9 chromosome.3 Since then, the study of large series by other authors has confirmed that the deleted portion translocated to chromosome 9 in the majority of cases of the disorder studied.4 , 5 Translocation on chromosomes 2, 17, 19 and 22 has . . .This publication has 6 references indexed in Scilit:
- Genesis of the Ph 1 ChromosomeJNCI Journal of the National Cancer Institute, 1974
- A NEW TRANSLOCATION RELATED TO THE PHILADELPHIA CHROMOSOMEThe Lancet, 1973
- A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa StainingNature, 1973
- A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMESThe Lancet, 1971
- Identification of the Philadelphia chromosome as a number 22 by quinacrine mustard fluorescence analysisExperimental Cell Research, 1970