The utility of magnetic resonance imaging and spectroscopy for predicting insignificant prostate cancer: an initial analysis

Abstract

OBJECTIVE To design new models that combine clinical variables and biopsy data with magnetic resonance imaging (MRI) and MR spectroscopic imaging (MRSI) data, and assess their value in predicting the probability of insignificant prostate cancer. PATIENTS AND METHODS In all, 220 patients (cT stage T1c or T2a, prostate‐specific antigen level 3 with no poorly differentiated elements. The accuracy of predicting insignificant prostate cancer was assessed using areas under receiver operating characteristic curves (AUCs), for previously reported clinical models and for newly generated MR models combining clinical variables, and biopsy data with MRI data (MRI model) and MRI/MRSI data (MRI/MRSI model). RESULTS At pathology, 41% of patients had insignificant cancer; both MRI (AUC 0.803) and MRI/MRSI (AUC 0.854) models incorporating clinical, biopsy and MR data performed significantly better than the basic (AUC 0.574) and more comprehensive medium (AUC 0.726) clinical models. The P values for the differences between the models were: base vs medium model, <0.001; base vs MRI model, <0.001; base vs MRI/MRSI model, <0.001; medium vs MRI model, <0.018; medium vs MRI/MRSI model, <0.001. CONCLUSIONS The new MRI and MRI/MRSI models performed better than the clinical models for predicting the probability of insignificant prostate cancer. After appropriate validation, the new MRI and MRI/MRSI models might help in counselling patients who are considering choosing deferred therapy.