Acid Ceramidase Overexpression Prevents the Inhibitory Effects of Saturated Fatty Acids on Insulin Signaling
Open Access
- 1 May 2005
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 280 (20), 20148-20153
- https://doi.org/10.1074/jbc.m412769200
Abstract
No abstract availableKeywords
This publication has 56 references indexed in Scilit:
- Effect of acute exercise and training on metabolism of ceramide in the heart muscle of the ratActa Physiologica Scandinavica, 2004
- Ceramide Disables 3-Phosphoinositide Binding to the Pleckstrin Homology Domain of Protein Kinase B (PKB)/Akt by a PKCζ-Dependent MechanismMolecular and Cellular Biology, 2003
- A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty AcidsJournal of Biological Chemistry, 2003
- Fatty Acid Infusion Selectively Impairs Insulin Action on Akt1 and Protein Kinase C λ/ζ but Not on Glycogen Synthase Kinase-3Published by Elsevier ,2002
- De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, PathwayJournal of Biological Chemistry, 2002
- Overexpression of Acid Ceramidase Protects from Tumor Necrosis Factor–Induced Cell DeathThe Journal of Experimental Medicine, 2000
- Biosynthesis of sphingolipids: Dihydroceramide and not sphinganine is desaturated by cultured cellsBiochemical and Biophysical Research Communications, 1992
- Inhibitory action of sphingosine, sphinganine and dexamethasone on glucose uptake: Studies with hydrogen peroxide and phorbol esterLife Sciences, 1990
- Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucoseBiochemical and Biophysical Research Communications, 1986
- THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUSThe Lancet, 1963