Physiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear wave
Open Access
- 28 July 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Pflügers Archiv - European Journal of Physiology
- Vol. 462 (4), 587-597
- https://doi.org/10.1007/s00424-011-0993-7
Abstract
This article presents a novel model of acupuncture physiology based on cellular calcium activation by an acoustic shear wave (ASW) generated by the mechanical movement of the needle. An acupuncture needle was driven by a piezoelectric transducer at 100 Hz or below, and the ASW in human calf was imaged by magnetic resonance elastography. At the cell level, the ASW activated intracellular Ca2+ transients and oscillations in fibroblasts and endothelial, ventricular myocytes and neuronal PC-12 cells along with frequency–amplitude tuning and memory capabilities. Monitoring in vivo mammalian experiments with ASW, enhancement of endorphin in blood plasma and blocking by Gd3+ were observed; and increased Ca2+ fluorescence in mouse hind leg muscle was imaged by two-photon microscopy. In contrast with traditional acupuncture models, the signal source is derived from the total acoustic energy. ASW signaling makes use of the anisotropy of elasticity of tissues as its waveguides for transmission and that cell activation is not based on the nervous system.Keywords
This publication has 18 references indexed in Scilit:
- Test–retest study of fMRI signal change evoked by electroacupuncture stimulationNeuroImage, 2006
- An fMRI study of somatosensory‐implicated acupuncture points in stable somatosensory stroke patientsJournal of Magnetic Resonance Imaging, 2006
- Acupuncture for Patients With MigraineJAMA, 2005
- Tissue displacements during acupuncture using ultrasound elastography techniquesJapanese Journal of Clinical Oncology, 2004
- In vivo monitoring of Ca2+ uptake into mitochondria of mouse skeletal muscle during contractionThe Journal of cell biology, 2004
- Reading the patterns in living cells —the physics of ca2+signalingAdvances in Physics, 2004
- Magnetic Resonance Elastography by Direct Visualization of Propagating Acoustic Strain WavesScience, 1995
- Calcium Channels, Stores, and OscillationsAnnual Review of Cell Biology, 1990
- Inositol phosphates and cell signallingNature, 1989
- Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cellsNature, 1988