Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells
- 1 September 1988
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 335 (6185), 40-45
- https://doi.org/10.1038/335040a0
Abstract
Measurement of cytoplasmic free calcium, [Ca2+]i, in single human endothelial cells has shown that low doses of the inflammatory mediator histamine evoke asynchronous repetitive spikes in [Ca2+]i whereas high doses cause a maintained elevated [Ca2+]i. We discuss possible regulatory mechanisms, and the potential physiological and pathological implications of such a frequency-modulated [Ca2+]i signalling system.Keywords
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