Insulin-like immunoreactivity in the human brain
- 1 January 1982
- journal article
- research article
- Published by Springer Nature in Histochemistry and Cell Biology
- Vol. 74 (2), 293-300
- https://doi.org/10.1007/bf00495838
Abstract
The localization and regional distribution of insulin-like immunoreactivity (IRI) was studied in human brain autopsy material using the indirect immunofluorescence technique. A positive reaction for IRI could be observed in many neurons of the hypothalamus, the hippocampus, corpus amygdaloideum, medulla oblongata (especially within the nuclei of cranial nerves IX, X and XII), and the cerebral cortex, whereas the cerebellar cortex was lacking in immunohistochemically detectable insulin-like material. No nerve fibres containing polypeptides could be revealed. Additionally, the inuslin content of various brain regions was estimated by radioimmunosassay. Insulin concentrations in human nervous tissue were found to be elevated in comparison to blood plasma levels.Keywords
This publication has 12 references indexed in Scilit:
- Insulin stimulates sodium-potassium activated ATPase from rat hippocampusCellular and Molecular Life Sciences, 1981
- Poor evidence for insulin/insulin-like immunoreaetivity in the CNS of lower vertebratesActa Histochemica, 1981
- Insulin immunohistochemistry of rodent CNS: Apparent species differences but good correlation with radioimmunological dataHistochemistry and Cell Biology, 1981
- Peptidergic neuronesNature, 1980
- Stimulation of Ornithine Decarboxylase Activity by Insulin in Developing Rat Brain*Endocrinology, 1980
- An immunofluorescent reaction appears to insulin-antiserum in different CNS regions of two rat speciesActa Histochemica, 1980
- CELLULAR LOCALIZATION OF INSULIN-LIKE IMMUNOREACTIVITY IN THE CENTRAL NERVOUS SYSTEM OF SPINY MICE, C57B16J AND C57B1KSJ MICEACTA HISTOCHEMICA ET CYTOCHEMICA, 1980
- Is insulin 'native' to many tissues?Published by American Medical Association (AMA) ,1979
- Immunofluorescent localization of insulin-like material in the median neurosecretory cells of the blowfly, Calliphora vomitoria (Diptera)Cell and tissue research, 1979
- Identification of insulin in rat brain.Proceedings of the National Academy of Sciences, 1978