Plasma Levels of Diazepam After Parenteral and Rectal Administration in Children
- 1 June 1975
- Vol. 16 (2), 277-283
- https://doi.org/10.1111/j.1528-1157.1975.tb06058.x
Abstract
Plasma levels of diazepam and N-desmethyldiazepam were investigated in 19 children by a gas chromatographic method permitting the use of capillary sample. Intravenous administration was studied in 3 children and the plasma level curves showed a rapid decline during the first hour. Absorption and elimination after rectal administration of a solution in 16 children were similar to those after intramuscular administration. Diazepam given by suppository to 5 children gave much lower plasma levels and delayed time to peak levels. Recurrence of seizures in 2 children indicated that the anticonvulsants plasma level was of the order of 150 to 200 mug/liter. No significant side effects were observed. Thus rectal administration of a solution of diazepam is a practical method to arrest convulsions in children.Keywords
This publication has 9 references indexed in Scilit:
- Diazepam Treatment for Acute Convulsions in ChildrenEpilepsia, 1974
- Pharmacokinetic Profile of Diazepam in Man following Single Intravenous and Oral and Chronic Oral AdministrationsJournal of Pharmaceutical Sciences, 1973
- Diazepam elimination in premature and full term infants, and childrenjpme, 1973
- Determination of bioavailability of diazepam in various formulations from steady state plasma concentration dataClinical Pharmacology & Therapeutics, 1972
- Anticonvulsant activity and brain levels of diazepam and its metabolites in miceEuropean Journal of Pharmacology, 1971
- Salicylate Absorption from Rectal SuppositoriesJournal of Pharmaceutical Sciences, 1971
- PLASMA LEVELS OF THIOPENTONE AFTER PREMEDICATION WITH RECTAL SUPPOSITORIES IN YOUNG CHILDRENBritish Journal of Anaesthesia, 1969
- Treatment of Status Epilepticus in Neurosurgical Patients with Diazepam (‘Valium‘)International Journal Of Clinical Practice, 1968
- Eine neue Therapiem glichkeit des Status epilepticus im Kindesalter mit Valium i.v.European Journal of Pediatrics, 1966