Decrease in Thalamic Volumes of Pediatric Patients With Obsessive-compulsive Disorder Who Are Taking Paroxetine

Abstract

OBSESSIVE-COMPULSIVE disorder (OCD) has a lifetime prevalence of 2% to 3%^1-3 with pediatric onset in as many as 80% of cases.⁴ Investigation of the developmental neurobiology of the disorder is, therefore, best accomplished by studying early onset illness in childhood to minimize potentially confounding factors of long-term illness duration and treatment intervention.