Chemical Inhibition of the Growth of the Virus of Influenza in Embryonated Eggs

Abstract

Nitroakridin 3582, the related compound, rutenol, 2 nitro 5 aminoacridine, and cobaltous salts retarded and, in some instances, prevented the growth of small inocula of the viruses of influenza in embryonated eggs. In the case of nitroakridin, the most active compound in this respect, the inhibitory effect was most marked during the early phases of viral growth. Nitroakridin exerted little antiviral activity in vitro and it is suggested that the observed effect on viral growth was secondary to the effect of nitroakridin on the embryonated egg. Nitroakridin 3582 had no chemotherapeutic effect on infections with the viruses of influenza in mice.