The Inactivation of Streptomycin and its Practical Applications.

Abstract
The antibacterial activity of streptomycin is greatly reduced by a number of chemical agents. These include glucose and certain other sugars, cevitamic acid, cysteine, ketone reagents and an anaerobic environment. The inactivation by sugars and by anaerobic conditions seem to be due to the acidity produced. The effect of cysteine, cevitamic acid, and ketone reagents may result from the interaction between streptomycin and these substances to give inactive products.