Antigenic Determinants in Fragments of Gamma Globulin from Rabbit Serum
- 29 March 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 139 (3561), 1292-1293
- https://doi.org/10.1126/science.139.3561.1292
Abstract
Peptic digestion of fraction III from papain-digested rabbit serum γ-globulin produces a variety of smaller fragments. Some are too large to pass through a dialysis bag, and these retain the capacity to precipitate with antiserum to rabbit γ-globulin. Others pass through the bag and fail to precipitate with antibody, but they can inhibit the precipitation of antibody with fraction III. This indicates that antigenic determinants of the γ-globulin molecule are carried in these fragments.Keywords
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