BREATHING MODE OF CONFORMATIONAL FLUCTUATIONS IN GLOBULAR PROTEINS
- 1 July 1975
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 7 (4), 333-334
- https://doi.org/10.1111/j.1399-3011.1975.tb02448.x
Abstract
Globular proteins in the native state are assumed to behave as continuous elastic spheres in the low frequency breathing motions. Reasonable values of Young's modulus E = 10(11) dyne/cm2 and the radius of the sphere ro = 20 A, yield a wave number of 26 cm-1 for the fundamental vibration of the sphere. The peak at around 30 cm-1 in the laser Raman spectra of native alpha-chymotrypsin and pepsin observed by Brown et al. might be assigned to the breathing motion which the native proteins undergo as continuous elastic bodies.Keywords
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