EFFECT OF LOCAL APPLICATION OF PROGESTERONE ON THE RABBIT UTERUS

Abstract

Crystalline progesterone introduced directly within the lumen of theelin-sensitized immature rabbits produced characteristic progestational proliferation of the endo-metrium. Single applications of 0.0005 to 0.005 mg. in 0.1 cc of peanut oil or lanolin in segments of uterus 3 to 4 cm. in length caused reactions in 72 hrs. equivalent to those obtained with 0.5 mg. progesterone administered in divided doses intramusc. in the intact animal. Application of 0.000125 to 0.00025 mg. produced endometrial threshold reactions.