A note on the identification of sulphonamides by thin-layer chromatography
- 1 November 1970
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 22 (11), 845-847
- https://doi.org/10.1111/j.2042-7158.1970.tb08450.x
Abstract
A method is described for the identification of 25 sulphonamides by thin layer chromatography. Four systems are used, the solvents being (I) chloroform-methanol (4:1), (II) chloroform-carbon tetrachloride-methanol (7:2:1), (III) ethyl acetate-methanol (9:1), (IV) acetone-methanol (4:1), the plates being coated with silica gel G mixed with (I) sodium hydroxide, (II) potassium hydrogen sulphate, (III) water, (IV) sodium hydroxide. The location reagents are (a) copper sulphate, (b) p-dimethylamino-benzaldehyde, (c) N(1-napthyl) ethylenediamine di-HCl, and (d) fluorescein.Keywords
This publication has 4 references indexed in Scilit:
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- Thin-layer chromatography on zinc ferrocyanideJournal of Chromatography A, 1965
- Thin-Layer Chromatography in Drug Analysis II. Procedure for the Identification of Various N4-Substituted SulfonamidesJournal of Pharmaceutical Sciences, 1963
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